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 | Cardiovascular System |
Heart failure is a life-threatening condition that affects a large portion of the population in Western societies. NIRM aims to
- Identify molecular factors (genetic/epigenetic) that lead to the generation and amplification of cardiomyocyte stem cells and progenitor cells, in order to improve cardiomyocyte growth (inside and outside the body). The improved growth can subsequently be implemented with other cell components of the normal functioning heart (such as vasculature endothelium or smooth muscle) to facilitate cardiac repair.
- Establish patient-derived iPS cells for development of myocardium.
- Develop novel therapeutic approaches to enhance the mobilization of endothelial progenitor cells (EPC) and pro-angiogenic factors from bone marrow.
- Generate stable perfused and well-organized vessels in ischemic and grafted tissues and biomaterials.
- Construct synthetic human myocardium.
- Develop humanized in vitro models to investigate the effect of soluble factors on endothelial progenitor cell (EPC) behavior.
- Develop supra-molecular biomaterials that are able to adapt their functionalities to the cells and the environment they encounter.
